Twinlab Forskolin Fat Loss Supplement Review

Picked up a couple bottles of Twinlab Diet Fuel Forskolin on a BOGOF. I have been on my fat loss cut for 19 weeks now, which out of my past three cuts is the longest duration so far.

By no means has this cut being "harsh" but after a prolonged period of time in a deficit I want to make sure everything is firing as it should and optimal metabolism achieved on the way back up. That's where Forskolin comes in...

In a nutshell; when you are in a caloric deficit for long periods of times both Thyroid and cAMP production is reduced. To better improve fat loss and metabolism; both these levels need to be increased / returned to normal, optimal levels.

Taken from: http://www.naturodoc.com/forskolin.htm

How Forskolin Works

"Forskolin acts primarily by activating the enzyme adenylate cyclase, which results in increased cyclic adenosine monophosphate (cAMP) in cells. Cyclic AMP belongs to a class of substances known as "second messengers" and is one of the most important cell-regulating compounds. Among its many roles, cAMP activates numerous other enzymes involved in diverse cellular functions. Hormones and neurotransmitters also activate adenylate cyclase, but Forskolin appears to be able to activate adenylate cyclase by itself. Thus, Forskolin can increase cyclic AMP without the assistance of hormones or neurotransmitters."

Effects of Cyclic AMP

"Increased cellular cyclic AMP results in a broad range of physiological and biochemical effects, including inhibition of platelet activation (resulting in decreased likelihood of blood clots), reduced release of histamine (resulting in decreased allergy symptoms), increased force of contraction of the heart, relaxation of the arteries and other smooth muscles, increased thyroid function, and increased lipolysis (fat burning).

A number of diseases are characterized, in part, by decreased intracellular levels of cyclic AMP. These include asthma, eczema, psoriasis, angina, obesity and hypertension. In addition to its adenylyl cyclase-stimulating actions, Forskolin also appears to have actions that are not due to this mechanism, but are due to its ability to alter a number of membrane transport proteins."

Weight Loss

"In vitro studies show that Forskolin stimulates lipolysis (breaking down of fats) in fat cells. Additionally, scientists at the Penn State University College of Medicine have found that many obese people have lower than normal cAMP production. Based on these findings and in vitro studies, scientists theorized that Forskolin might be an effective weight loss agent, especially for those with impaired cAMP production. A recent small study appeared to confirm this conjecture. Six overweight women took 25 mg of Forskolin (250 mg capsules of 10 percent standardized Forskolin extract) twice daily for eight weeks. At the end of the eight-week trial, the participants lost a mean of ten pounds, and reduced their percentage of body fat by nearly 8 percent. Blood pressure levels also trended lower during the trial. These preliminary results indicate that Forskolin may be a safe, useful adjunct to losing weight and maintaining normal body composition."

Hypothyroidism (Low Thyroid Output)

"Forskolin also has demonstrated the ability to increase thyroid hormone production and stimulate thyroid hormone release. This mechanism of stimulating the thyroid to enhance metabolism may be one way in which Forskolin promotes normal body weight. Forskolin's effects in normalizing thyroid function may also contribute to its antidepressant effects, as depression is a common feature of hypothyroidism."

Dosage

"Based on the human studies for weight loss, 50 to 100 mg of Forskolin taken in divided doses during the day appears to be a safe, effective dose for the conditions discussed above."

Other useful information, taken from Wikipedia:

cAMP: http://en.wikipedia.org/wiki/Cyclic_adenosine_monophosphate

Hypothyroidism: http://en.wikipedia.org/wiki/Hypothyroidism

Remember... you have to be in a CALORIC DEFICIT in order to lose weight / achieve fat loss!

Thanks for watching!

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